It takes a long, long time for caffeine to completely leave your system, with its zippy side effects gradually wearing off as time passes and your body metabolizes it. Typically, the half-life of caffeine is around four to six hours, according to the Food and Drug Administration (FDA), meaning that four to six hours after consumption, about half of that caffeine is still in your system. At this point, you may still be feeling some stimulant effects of the caffeine. Then, another four to six hours later, half of that amount is gone. If you drink a cup of coffee containing 100 mg of caffeine at 10 a.m. (about one 8-ounce cup of coffee) as much as 25 mg may still be in your system when you lay down at 10 p.m., whereas if you drink 200 mg at 4 p.m. (two-ish 8-ounce cups), about 100 mg can still be in your system at 10 p.m.
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